Clatterbridge Hospital is among the first 50 hospital hubs in the country to start delivering the ground-breaking coronavirus vaccine this week.
The Wirral hospital has been selected as the NHS begin vaccinating patients against Covid-19 at the start of the biggest immunisation programme in history.
People aged 80 and over as well as care home workers will be first to receive the jab, along with NHS workers who are at higher risk.
NHS staff worked through the weekend to prepare for the launch of the programme with the first vaccinations happening from Tuesday.
Janelle Holmes Chief Executive at Wirral University Teaching Hospital said: "We are proud to be one of the first 50 Trusts to roll out the vaccine in England and be part of the largest vaccination programme this country has ever seen.
"We have been planning for this for some time and are ready to begin safely vaccinating those at greatest risk as soon as we receive the vaccine in the coming days.
"We would also like to thank our staff who have worked tirelessly reconfiguring our estate to create a vaccine hub, to prepare our pharmacy and storage; and who are preparing to move onto vaccinations from their normal jobs."
There are 50 hubs in the first wave and more hospitals will start vaccinating over the coming weeks and months as the programme ramps up.
Patients aged 80 and above who are already attending hospital as an outpatient, and those who are being discharged home after a hospital stay, will be among the first to receive the life-saving jab.
Hospitals will also begin inviting over 80s in for a jab and work with care home providers to book their staff in to vaccination clinics.
Any appointments not used for these groups will be used for healthcare workers who are at highest risk of serious illness from covid. All those vaccinated will need a booster jab 21 days later.
GPs and other primary care staff are also being put on standby to start delivering the jab. A small number of GP-led primary care networks will begin doing so during the following week (commencing December 14) with more practices across the UK joining in on a phased basis.
Vaccination centres treating large numbers of patients in sporting venues and conference centres will subsequently stand up when further supplies of vaccine come on stream.
Professor Stephen Powis, NHS national medical director, said: “Despite the huge complexities, hospitals will kickstart the first phase of the largest scale vaccination campaign in our country’s history from Tuesday. The first tranche of vaccine deliveries will be landing at hospitals by Monday in readiness.
“The NHS has a strong record of delivering large scale vaccination programmes – from the flu jab, HPV vaccine and lifesaving MMR jabs – hardworking staff will once again rise to the challenge to protect the most vulnerable people from this awful disease.”
The life-saving vaccine is typically delivered by a simple injection in the shoulder but there is a complex and difficult logistical challenge to deliver from the manufacturers Pfizer to patients.
It needs to be stored at -70C before being thawed out and can only be moved four times within that cold chain before being used.
NHS staff have been working over the weekend to prepare the sites and accept deliveries.
Health Secretary Matt Hancock said: “This coming week will be an historic moment as we begin vaccination against COVID-19.
“We are prioritising the most vulnerable first and over-80s, care home staff and NHS colleagues will all be among the first to receive the vaccines.
“We are doing everything we can to make sure we can overcome significant challenges to vaccinate care home residents as soon as possible too.
“I urge everybody to play their part to suppress this virus and follow the local restrictions to protect the NHS while they carry out this crucial work.”
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